04 Drug Elimination
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![](https://photos.thisispiggy.com/file/wikiFiles/CC2FF6AB-6200-45B0-8710-086FEE2D4200.jpg)
Zero Order
![](https://photos.thisispiggy.com/file/wikiFiles/BA767838-A807-46D2-AE5D-CB2FD07B9386.jpg)
- for each unit of time (horizontal line), eliminate 5 units
- rate is constant x drug concentration to 0th power
- know the drugs
First order
![](https://photos.thisispiggy.com/file/wikiFiles/8EAA072F-F2E7-4D6E-B78B-4A0F27236295.jpg)
- unit change is varying, percent change same
- time it takes to fall from 4 to 2 is same as time takes from 2 to 1
![](https://photos.thisispiggy.com/file/wikiFiles/48EC6377-9EF7-4C5F-84BA-5A4BAC8836A5.jpg)
Elimination
![](https://photos.thisispiggy.com/file/wikiFiles/E98E6331-221E-4B82-8B6C-9F6C6043377E.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/9F705388-3BC5-4D6A-89C1-7A6380D1B2F9.jpg)
- more blood flow = more elimination
![](https://photos.thisispiggy.com/file/wikiFiles/9858020D-0BF8-47EF-894A-0A594635D81E.jpg)
- at high concentration of drug, drug operating at Vmax rate = zero order operation
Urine pH
![](https://photos.thisispiggy.com/file/wikiFiles/F666A9BF-37D3-4289-B967-D7306A1FA8EA.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/A6783CF4-1B10-4AA3-BB0C-BD8B3C72C077.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/24043FA0-97E5-486A-B932-C5D0840E0A6B.jpg)
- acidic urine: favors HA form and reabsorption
- alkaline urine: favors BOH and reabsorption
![](https://photos.thisispiggy.com/file/wikiFiles/F3E5CB20-046E-4D4B-A0A6-67CD35CCBC51.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/A91C2793-AE5E-4424-92CD-B09DBC1A2932.jpg)
Phase 1
![](https://photos.thisispiggy.com/file/wikiFiles/D2F8297A-7351-4B48-9DCA-84041521F437.jpg)
- active, not ready for excretion
- prodrug to drug
![](https://photos.thisispiggy.com/file/wikiFiles/9576AF93-0D23-4403-B694-278B01C802F7.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/8FBA7332-F9AC-4A94-9590-7711B9FA5E64.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/CB837B8D-EE5C-4E1E-AFDB-9B177D85EEA4.jpg)
Phase 2
![](https://photos.thisispiggy.com/file/wikiFiles/D4AE9F71-2082-49BA-AA95-0E80A420FD47.jpg)
- very polar inactive to kidney for excretion
![](https://photos.thisispiggy.com/file/wikiFiles/CD87FCDC-7EC4-454C-8AAD-153445428DFD.jpg)
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